Scientists used to think bone marrow was sterile, but now we know it has bacteria, fungi, and viruses, including SARS-CoV-2. This virus can damage the marrow and immune system, possibly leading to infections like Staph or Candida, especially in Long Covid. Studies also found viruses like Epstein Barr in marrow, which may worsen illnesses. More research is needed to understand this microbiome and its effects on health.
The bone marrow(BM)of healthy people is colonised by billions of bacteria, fungi & viruses. However, until recently the BM was thought to be sterile but we now know it isn't. SARS-CoV-2 infects the bone marrow & it certainly damages the immune system there. Then for some (1/5)
it persists causing further damage of both the tissue & immune system; this would allow the overgrowth of dangerous opportunistic pathogens such as Staph A & Candida in the bone marrow. I suspect this is occurring in some people with Long Covid.(2/5)
The link is to a study where the team analysed the bone marrow of people with MDS cancer. Epstein Barr virus (EBV) was the most commonly found virus. Higher EBV virus numbers correlated with poorer outcomes in people with cancer in the study. The team(3/5)
speculated on whether this was a mechanism for worse cancer outcomes. We need to start conducting more studies into the bone marrow microbiome - and not just in cancer - as this would give us insights into the role of microbes causing bone marrow infections (4/5)
and how it may be causing illnesses, immune damage, bone & muscle diseases such as arthritis, & blood disorders. (5/5)
The bone marrow(BM)of healthy people is colonised by billions of bacteria, fungi & viruses. However, until recently the BM was thought to be sterile but we now know it isn't. SARS-CoV-2 infects the bone marrow & it certainly damages the immune system there. Then for some (1/5)it persists causing further damage of both the tissue & immune system; this would allow the overgrowth of dangerous opportunistic pathogens such as Staph A & Candida in the bone marrow. I suspect this is occurring in some people with Long Covid.(2/5)The link is to a study where the team analysed the bone marrow of people with MDS cancer. Epstein Barr virus (EBV) was the most commonly found virus. Higher EBV virus numbers correlated with poorer outcomes in people with cancer in the study. The team(3/5)speculated on whether this was a mechanism for worse cancer outcomes. We need to start conducting more studies into the bone marrow microbiome - and not just in cancer - as this would give us insights into the role of microbes causing bone marrow infections (4/5)and how it may be causing illnesses, immune damage, bone & muscle diseases such as arthritis, & blood disorders. (5/5)
The bone marrow(BM)of healthy people is colonised by billions of bacteria, fungi & viruses. However, until recently the BM was thought to be sterile but we now know it isn't. SARS-CoV-2 infects the bone marrow & it certainly damages the immune system there. Then for some (1/5) ... it persists causing further damage of both the tissue & immune system; this would allow the overgrowth of dangerous opportunistic pathogens such as Staph A & Candida in the bone marrow. I suspect this is occurring in some people with Long Covid.(2/5) ... The link is to a study where the team analysed the bone marrow of people with MDS cancer. Epstein Barr virus (EBV) was the most commonly found virus. Higher EBV virus numbers correlated with poorer outcomes in people with cancer in the study. The team(3/5) ... speculated on whether this was a mechanism for worse cancer outcomes. We need to start conducting more studies into the bone marrow microbiome - and not just in cancer - as this would give us insights into the role of microbes causing bone marrow infections (4/5) ... and how it may be causing illnesses, immune damage, bone & muscle diseases such as arthritis, & blood disorders. (5/5)
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